Myocilin Gene Variants and High Myopia in Europeans
Author Information
Author(s): Zayats Tetyana, Yanovitch Tammy, Creer Rosalind C., McMahon George, Li Yi-Ju, Young Terri L., Guggenheim Jeremy A.
Primary Institution: Cardiff University
Hypothesis
Is there an association between high myopia and polymorphisms in the myocilin gene in subjects of European ethnicity?
Conclusion
MYOC polymorphisms have a very low, or possibly negligible, influence on high myopia susceptibility in subjects of European ethnicity.
Supporting Evidence
- Two MYOC variants showed significant association before correction for multiple testing.
- No significant association was found after Bonferroni correction.
- The estimated relative risk conferred by MYOC variants was low.
Takeaway
The study looked at a gene that might be linked to nearsightedness in Europeans and found that it doesn't really affect how likely someone is to be nearsighted.
Methodology
Subjects were recruited from Cardiff University and Duke University, and DNA was genotyped for MYOC SNPs to assess association with high myopia.
Potential Biases
There may be risks of bias due to differences in allele frequencies and disease prevalence between the UK and USA cohorts.
Limitations
The study may have lacked power to detect associations due to the modest sample size and potential population stratification.
Participant Demographics
All subjects were of Caucasian ethnicity.
Statistical Information
P-Value
p=0.043 for rs16864720 and p=0.026 for NGA17 before correction.
Confidence Interval
RR<1.5 for both variants.
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