Pregnancy and risk of renal cell cancer: a population-based study in Sweden
2002
Pregnancy and Risk of Renal Cell Cancer
Sample size: 1465
publication
Evidence: high
Author Information
Author(s): Mats Lambe, Per Lindblad, Jian Wuu, Rachel Remler, Chih-Cheng Hsieh
Primary Institution: Karolinska Institutet
Hypothesis
Is there an association between childbearing and the risk of renal cell cancer?
Conclusion
Women with a history of high parity are at an increased risk of renal cell cancer.
Supporting Evidence
- Ever-parous women had a 40% increased risk of RCC compared to nulliparous women.
- Women with five or more live births had an odds ratio of 1.91 for RCC.
- Each additional birth was associated with a 15% increase in RCC risk.
Takeaway
Having more children may increase a woman's risk of kidney cancer.
Methodology
A nested case-control study using data from the Fertility Register and Cancer Register in Sweden.
Potential Biases
Potential uncontrolled confounding by BMI.
Limitations
Lack of information on potential confounders such as BMI, weight cycling, hypertension, and smoking habits.
Participant Demographics
Swedish women born between 1925 and 1972.
Statistical Information
P-Value
1.42
Confidence Interval
1.19-1.69
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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