Methyl 2-(2-{[(benzyloxy)carbonyl]amino}propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate
2011
Study of a Key Intermediate in Raltegravir Preparation
publication
Evidence: moderate
Author Information
Author(s): Shang Zhenhua, Ha Jing, Yu Yifeng, Zhao Xiaodan
Primary Institution: Hebei University of Science and Technology
Hypothesis
The title compound is an intermediate in the preparation of the anti-retroviral drug raltegravir.
Conclusion
The crystal structure of the compound is stabilized through intermolecular and intramolecular hydrogen bonds.
Supporting Evidence
- The dihedral angle between the two aromatic rings in the compound is 45.9°.
- The crystal structure is stabilized through intermolecular N—H⋯O hydrogen bonds.
- Intramolecular O—H⋯O hydrogen bonds are also present.
Takeaway
This study looks at a chemical compound that helps make a medicine for treating HIV. It shows how the compound is structured and how it holds together.
Methodology
The compound was prepared using a published method involving several chemical reactions and crystallization steps.
Digital Object Identifier (DOI)
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