Puerarin Suppresses Invasion and Vascularization of Endometriosis Tissue Stimulated by 17β-Estradiol
Author Information
Author(s): Wang Dan, Liu Yuhuan, Han Jie, Zai Dongxia, Ji Mei, Cheng Wen, Xu Ling, Yang Luxi, He Miaoxia, Ni Jian, Cai Zailong, Yu Chaoqin
Primary Institution: Changhai Hospital, Second Military Medical University, Shanghai, China
Hypothesis
Can puerarin suppress the invasion and vascularization of E2-stimulated endometriotic tissue?
Conclusion
Puerarin can suppress the tissue invasion by ESCs and the vascularization of ectopic endometrial tissues stimulated by E2.
Supporting Evidence
- Puerarin significantly reversed the effects of E2 on ESC invasiveness (P<0.01).
- Puerarin inhibited angiogenesis in endometriotic tissue stimulated by E2 (P<0.05).
- The purity of ESCs in isolated cells was >95%.
Takeaway
Puerarin is a natural compound that helps stop the growth of endometriosis by blocking the effects of estrogen.
Methodology
The study used Transwell Assays to assess the invasive ability of endometriotic stromal cells and CAM assays to observe vascularization.
Participant Demographics
Premenopausal patients who had undergone surgery for ovarian endometriotic cysts.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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