How much is too much?: A study on fluid balance in septic patients
Author Information
Author(s): Yang Zheng, Shi Zhanli, Song Wenwen
Primary Institution: Hangzhou Red Cross Hospital, Hangzhou, China
Hypothesis
Overly aggressive fluid strategy in patients with sepsis can lead to adverse outcomes.
Conclusion
A 7-day fluid balance greater than 5240 mL is associated with poor outcomes in septic patients.
Supporting Evidence
- The median 7-day fluid balance was 5321.4 mL.
- The observed 28-day mortality in the cohort was 21.6%.
- A fluid balance of <5243.3 mL was considered protective, while >5243.3 mL was a risk factor for mortality.
Takeaway
This study found that giving too much fluid to patients with sepsis can be harmful, and it's better to keep the fluid amount below 5240 mL over a week.
Methodology
A retrospective cohort study using data from the MIMIC-IV database, analyzing the 7-day fluid balance of septic patients and its correlation with mortality.
Potential Biases
Potential biases related to retrospective data collection and lack of control over fluid types and timing.
Limitations
The study did not subdivide the types of fluids used and did not restrict the timing of initial fluid resuscitation.
Participant Demographics
Adult patients with sepsis, average age around 64 years, with a mix of genders.
Statistical Information
P-Value
<0.001
Confidence Interval
not provided
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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