Regulatory T Cells and Their Role in Rheumatic Diseases
Author Information
Author(s): Milojevic Diana, Nguyen Khoa D, Wara Diane, Mellins Elizabeth D
Primary Institution: Department of Pediatrics, UCSF and Stanford University
Hypothesis
Regulatory T cells play a crucial role in limiting immune reactions and may serve as potential targets for novel therapeutic development in rheumatic diseases.
Conclusion
The study highlights the importance of CD4+CD25high regulatory T cells in rheumatic diseases and their potential for use in immunotherapy.
Supporting Evidence
- CD4+CD25high regulatory T cells are essential for maintaining self-tolerance.
- These cells can suppress immune responses and may be involved in the pathogenesis of autoimmune diseases.
- Therapeutic strategies targeting regulatory T cells could improve treatment outcomes in rheumatic diseases.
Takeaway
Regulatory T cells help keep our immune system from attacking our own body, and scientists think they could be used to help treat diseases where the immune system goes wrong.
Methodology
The article reviews existing literature on the phenotype, function, and development of CD4+CD25high regulatory T cells and their role in rheumatic diseases.
Limitations
The review is based on existing literature, which may have varying methodologies and results.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website