Exercise Training to Improve Muscle Strength in Multiple Myeloma Patients Before Transplant
Author Information
Author(s): Leung Tiffany, Normann Amber J, Mo Clifton C, Wilson Rebekah L, Perez Michelle, Cutler Corey, Uno Hajime, Thompson LaDora V, Skinner Tina L, Richardson Paul G, Marinac Catherine R, Dieli-Conwright Christina M
Primary Institution: Dana-Farber Cancer Institute
Hypothesis
Prehabilitative aerobic and resistance exercise will improve lower limb muscle strength prior to receiving ASCT and 30 days posttransplant in the exercise group compared to the waitlist control group.
Conclusion
We expect exercise to improve lower limb muscle strength and overall health outcomes compared to the waitlist control group.
Supporting Evidence
- Muscle mass and strength are severely compromised in patients diagnosed with multiple myeloma.
- 51% of patients experience low muscle mass and strength at the time of autologous stem cell transplant.
- Exercise training has been shown to improve physical fitness outcomes in patients with multiple myeloma.
Takeaway
This study is about helping people with multiple myeloma get stronger before their transplant by doing special exercises at home.
Methodology
This is a prospective, 2-armed single-center randomized controlled trial with 30 patients assigned to either an exercise or waitlist control group, involving an 8-week home-based exercise intervention.
Potential Biases
Digital training may restrict the assessment of full range of motion and participant state.
Limitations
Limited sample size and short duration of exercise.
Participant Demographics
Patients aged 18 years and older diagnosed with multiple myeloma scheduled for ASCT.
Digital Object Identifier (DOI)
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