Genetic Factors Affecting n-3 Fatty Acids in Blood
Author Information
Author(s): Lemaitre Rozenn N., Tanaka Toshiko, Tang Weihong, Manichaikul Ani, Foy Millennia, Kabagambe Edmond K., Nettleton Jennifer A., King Irena B., Weng Lu-Chen, Bhattacharya Sayanti, Bandinelli Stefania, Bis Joshua C., Rich Stephen S., Jacobs David R. Jr., Cherubini Antonio, McKnight Barbara, Liang Shuang, Gu Xiangjun, Rice Kenneth, Laurie Cathy C., Lumley Thomas, Browning Brian L., Psaty Bruce M., Chen Yii-Der I., Friedlander Yechiel, Djousse Luc, Wu Jason H. Y., Siscovick David S., Uitterlinden André G., Arnett Donna K., Ferrucci Luigi, Fornage Myriam, Tsai Michael Y., Mozaffarian Dariush, Steffen Lyn M.
Hypothesis
How does common genetic variation influence plasma phospholipid levels of n-3 polyunsaturated fatty acids?
Conclusion
The study found that genetic variations in certain genes significantly influence the levels of n-3 fatty acids in the blood.
Supporting Evidence
- The study analyzed data from five population-based cohorts.
- Genetic variants in the FADS1 and FADS2 genes were associated with higher ALA levels.
- The study identified a novel association of DPA with SNPs in the GCKR gene.
- The findings suggest that genetic variation influences the conversion of ALA to longer-chain n-3 fatty acids.
Takeaway
Some people have genes that help them turn plant fats into fish fats better than others, which is important for health.
Methodology
The study conducted a meta-analysis of genome-wide association studies involving 8,866 participants of European ancestry.
Limitations
The study primarily focused on participants of European ancestry, which may limit the generalizability of the findings to other populations.
Participant Demographics
Participants were of European ancestry, aged 21 to 102 years.
Statistical Information
P-Value
p<0.05
Digital Object Identifier (DOI)
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