The Impact of Dietary Protein Restriction on White Adipose Tissue Function During Aging
Author Information
Author(s): Young Khristina, Easter Molly, Vaddi Prerana, Donkor Michael, Wong Meghan, Hill Cristal
Primary Institution: University of Southern California
Hypothesis
Is browning of white adipose tissue via Prdm16 essential to improve metabolic health during dietary protein restriction, and are these improvements sex dependent?
Conclusion
Dietary protein restriction induces browning in white adipose tissue, which may improve metabolic health in a sex-dependent manner.
Supporting Evidence
- Dietary protein restriction can improve metabolism and overall health.
- Dietary protein restriction induces browning in white adipose tissue.
- PRDM16 plays a key role in regulating the function of adipose tissue.
- Improvements in metabolic health may be sex dependent.
Takeaway
Eating less protein can help our body's fat tissue work better as we get older, and this effect might be different for boys and girls.
Methodology
Mice were fed either a normal protein or a low-protein diet for 7 months to assess the effects on white adipose tissue.
Participant Demographics
3-month-old male and female normal-control and Prdm16 KO mice.
Digital Object Identifier (DOI)
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