Tumour enhancement with Mn-metalloporphyrin in MRI of mice
Author Information
Author(s): Takehara Y, Sakahara H, Masunaga H, Isogai S, Kodaira N, Takeda H, Saga T, Nakajima S, Sakata I
Primary Institution: Department of Radiology, Hamamatsu University School of Medicine
Hypothesis
The study aims to evaluate the tumour enhancing characteristics and biodistribution of a newly developed metalloporphyrin derivative, HOP-9P.
Conclusion
HOP-9P is a potential tumour-specific MR contrast agent.
Supporting Evidence
- The tumour/muscle signal intensity ratio at 24h was significantly higher than the precontrast ratio.
- HOP-9P accumulated in the tumour to reach the highest concentration at 24h.
Takeaway
Researchers tested a new substance that helps make tumors show up better in MRI scans of mice, and it worked well.
Methodology
Seven mice with tumors were imaged using MRI before and after injecting HOP-9P, and the biodistribution of manganese was measured in various tissues.
Participant Demographics
Mice bearing SCC VII tumors
Statistical Information
P-Value
P < 0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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