PLASMA PROTEOMIC SIGNATURE OF DEVELOPMENT AND PROGNOSIS OF PHYSICAL FRAILTY
2024
Proteins Linked to Frailty and Survival
Sample size: 43895
publication
Evidence: moderate
Author Information
Author(s): Xu Jianhong, Liu Jingyun, Liao Jinhui, Wu Chenkai
Primary Institution: Duke Kunshan University
Hypothesis
The study investigates the proteomic signature associated with the development and prognosis of frailty.
Conclusion
The study identified specific proteins that are associated with frailty and mortality, providing insights into potential therapeutic targets.
Supporting Evidence
- 210 proteins were associated with prefrailty at baseline.
- 268 proteins were associated with frailty at baseline.
- 109 proteins were linked to mortality among initially prefrail individuals.
- 80 proteins were linked to mortality among initially frail individuals.
- 60 proteins predicted survival in prefrail participants.
- 21 proteins predicted survival in frail participants.
Takeaway
Scientists looked at proteins in people's blood to see how they relate to being frail and how long people live.
Methodology
Data from participants was analyzed using multinomial logistic models, Cox models, and LASSO regression.
Participant Demographics
Participants were aged 39-70 years.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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