Study of MRSA in Örebro County, Sweden
Author Information
Author(s): Jan Kekki, Annethe Thegel, Bianca Stenmark, Bo Söderquist
Primary Institution: Örebro University, Örebro, Sweden
Hypothesis
How has the epidemiology of community-associated MRSA changed in Region Örebro County over 20 years?
Conclusion
The study found a shift in the dominant MRSA strains from ST80 to ST22 and an increase in strains from the Middle East.
Supporting Evidence
- MRSA prevalence increased from 2000 to 2019.
- ST80 was dominant from 2000-2010, while ST22 became dominant from 2011-2019.
- Resistance to trimethoprim increased significantly over the study period.
- Genotypic resistance to clindamycin also showed an upward trend.
Takeaway
This study looked at how a type of bacteria called MRSA changed in a specific area over 20 years, showing that new types are becoming more common.
Methodology
The study analyzed 330 MRSA isolates collected from 2000 to 2019 using whole genome sequencing and epidemiological data.
Limitations
The study is limited to Region Örebro County, which may not represent other regions, and lacks data on the country of origin for 20% of cases.
Participant Demographics
The study included MRSA isolates from a population of approximately 300,000 inhabitants in Region Örebro County.
Statistical Information
P-Value
p = 0.017
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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