Vitamin D3 Toxicity and Aloe Vera in Rats
Author Information
Author(s): Chavhan Sambhaji G., Brar R. S., Banga H. S., Sandhu H. S., Sodhi S., Gadhave P. D., Kothule V. R., Kammon A. M.
Primary Institution: GADVASU, Ludhiana, Punjab, India
Hypothesis
Does Aloe vera have a protective effect against vitamin D3 toxicity in rats?
Conclusion
The study found that Aloe vera had no protective effect against vitamin D3 toxicity in rats.
Supporting Evidence
- The study observed severe clinical signs like anorexia and weight loss in rats treated with vitamin D3.
- Significant increases in plasma calcium and phosphorus levels were noted in the treatment groups.
- Histopathological examination revealed calcification in various organs due to vitamin D3 toxicity.
- Aloe vera did not show any ameliorative effects on the clinical or biochemical parameters in the treated rats.
- Mortality was observed in treated rats between day 10 and day 19 of treatment.
Takeaway
This study looked at how vitamin D3 can make rats very sick and whether Aloe vera can help them feel better, but it didn't work.
Methodology
Thirty-two male Wistar albino rats were divided into four groups to assess the effects of vitamin D3 and Aloe vera.
Potential Biases
Potential bias in the selection of treatment dosages and the small sample size.
Limitations
The study only tested Aloe vera in a specific dosage and did not explore other potential treatments.
Participant Demographics
Thirty-two healthy adult male Wistar albino rats.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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