DEK Protein as a Biomarker for Bladder Cancer
Author Information
Author(s): Antara Datta, Martin E. Adelson, Yakov Mogilevkin, Eli Mordechai, Abraham A. Sidi, Jason P. Trama
Primary Institution: Oncoveda, Tumor Biology Center, Medical Diagnostic Laboratories, A Division of Genesis Biotechnology Group, Hamilton, New Jersey, USA
Hypothesis
Can DEK protein be used as a urinary biomarker for bladder cancer diagnosis?
Conclusion
DEK protein is expressed in bladder tumor tissue and voided urine of bladder cancer patients, suggesting it could be a useful biomarker for diagnosis.
Supporting Evidence
- DEK protein was found in 33 out of 38 bladder tumor tissues.
- 84% of urine samples from bladder cancer patients tested positive for DEK.
- DEK protein was not detected in adjacent normal tissues.
- DEK protein expression was consistent in both low and high grade tumors.
Takeaway
Doctors found a protein called DEK in the urine of people with bladder cancer, which might help them find the cancer earlier without needing to do a painful test.
Methodology
The study analyzed DEK protein expression in 38 bladder tumor tissues and 42 urine samples using western blot.
Potential Biases
Potential bias due to the limited number of healthy controls and the focus on diagnosed patients.
Limitations
The study had a small sample size and did not include a diverse range of healthy individuals.
Participant Demographics
Participants included 38 bladder cancer patients with a mean age of 76 years, predominantly male.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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