Antimicrobial Cryogel for Controlled Release of Ciprofloxacin
Author Information
Author(s): Bratskaya Svetlana, Boroda Andrey, Bogomaz Tamara, Privar Yuliya, Maiorova Mariya, Malyshev Daniil, Shindina Anastasiia, Skatova Anna, Goncharuk Roman
Primary Institution: Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences
Hypothesis
Can a new multifunctional carboxymethyl chitosan cryogel effectively control the loading and release of ciprofloxacin while maintaining fibroblast viability?
Conclusion
The CMC-Zn-CIP cryogels can suppress the growth of Klebsiella oxytoca while maintaining fibroblast viability at 85-90%.
Supporting Evidence
- CMC cryogels can be loaded with ciprofloxacin to suppress bacterial growth.
- Fibroblast viability was maintained at 85-90% with optimal ciprofloxacin loading.
- High Zn2+ content did not exhibit antibacterial properties due to strong binding.
Takeaway
This study created a special gel that can slowly release medicine to fight bacteria without hurting the healing cells.
Methodology
The study involved creating a carboxymethyl chitosan cryogel, loading it with ciprofloxacin, and testing its antibacterial properties and cytotoxicity.
Limitations
The study did not assess the effects of high Zn2+ content on fibroblasts in detail.
Digital Object Identifier (DOI)
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