Inflammatory Response Genes and Colorectal Cancer Risk
Author Information
Author(s): Suchy Janina, Kłujszo-Grabowska Ewa, Kładny Józef, Cybulski Cezary, Wokołorczyk Dominika, Szymańska-Pasternak Jolanta, Kurzawski Grzegorz, Scott Rodney J, Lubiński Jan
Primary Institution: Pomeranian Medical University, Szczecin, Poland
Hypothesis
Genetic variations in inflammatory response genes may act as modifiers of colorectal cancer risk.
Conclusion
The study suggests that certain genetic changes in inflammatory response genes can influence the risk of developing colorectal cancer, especially in older individuals.
Supporting Evidence
- Patients with chronic inflammatory bowel disease are at increased risk of colorectal cancer.
- The TNFα -1031 T/T genotype was found to be more common in colorectal cancer patients compared to controls.
- The study identified a suggestive association between the TNFα -1031 T/T genotype and colorectal cancer risk in older patients.
Takeaway
Some genes related to inflammation might make older people more likely to get colon cancer.
Methodology
The study analyzed polymorphisms in six inflammatory response genes in a group of colorectal cancer patients compared to matched controls.
Potential Biases
Potential for bias due to the relatively small sample size and the nature of genetic association studies.
Limitations
The study population size is relatively small, and some analyses may have increased the likelihood of false positives due to multiple comparisons.
Participant Demographics
The study included 607 colorectal cancer patients, with an average age of diagnosis of 63.2 years, and 607 matched controls.
Statistical Information
P-Value
0.02
Confidence Interval
1.87 (1.00–3.52)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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