Synthesis of (1-cyclopropyl)cyclopropylamine hydrochloride
Author Information
Author(s): Kozhushkov Sergei I, Khlebnikov Alexander F, Kostikov Rafael R, Yufit Dmitrii S, de Meijere Armin
Primary Institution: Institut für Organische und Biomolekulare Chemie der Georg-August-Universität Göttingen
Hypothesis
An alternative route to synthesize (1-cyclopropyl)cyclopropylamine hydrochloride from a carboxylic acid is proposed.
Conclusion
The new method allows for the scalable preparation of (1-cyclopropyl)cyclopropylamine hydrochloride in higher yields compared to previous methods.
Supporting Evidence
- The new synthesis method is reproducible on a 50 g scale.
- The yield of the new method is superior to previously published methods.
- The previous method required costly purification steps.
Takeaway
Scientists found a better way to make a special chemical that can help create medicines and pesticides, and they can make a lot of it at once.
Methodology
The synthesis involved a Curtius degradation of a carboxylic acid to produce the desired amine hydrochloride.
Limitations
The previous method required purification steps that were not easily scalable.
Digital Object Identifier (DOI)
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