Higher Levels of Fibroblast Growth Factor 8 in Breast Cancer and Lactating Breast
Author Information
Author(s): Zammit C, Coope R, Gomm J J, Shousha S, Johnston C L, Coombes R C
Primary Institution: Cancer Research (UK) Laboratories, Department of Cancer Medicine, Imperial College, Hammersmith Hospital
Hypothesis
Fibroblast growth factor 8 (FGF8) expression is increased in breast cancer and lactating human breast tissues.
Conclusion
The study confirms that FGF8 is expressed at higher levels in malignant breast tissue and lactating breast tissues compared to non-malignant tissues.
Supporting Evidence
- FGF8 expression was found to be significantly higher in malignant breast tissues compared to non-malignant tissues.
- The highest levels of FGF8 were detected in lactating breast tissues.
- FGF8 was also present in human milk, indicating its potential role in lactation.
Takeaway
This study found that a protein called FGF8 is more common in breast cancer and in the milk of breastfeeding mothers, which might help in understanding breast health.
Methodology
The study used immunohistochemistry to analyze FGF8 expression in 124 human breast tissue samples.
Limitations
The study did not include fetal tissue, which may have higher levels of FGF8.
Participant Demographics
The study included 85 breast cancer patients and various normal breast tissues.
Statistical Information
P-Value
0.5
Statistical Significance
p=0.5
Digital Object Identifier (DOI)
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