Pomegranate Extract and Its Effects on Inflammation
Author Information
Author(s): Meenakshi Shukla, Kalpana Gupta, Zafar Rasheed, Khursheed A Khan, Tariq M Haqqi
Primary Institution: Case Western Reserve University
Hypothesis
Does oral consumption of pomegranate fruit extract inhibit COX-2 activity and IL-1β-induced PGE2 production in human chondrocytes?
Conclusion
Pomegranate fruit extract constituents become bioavailable after ingestion and significantly inhibit COX-2 activity and the production of inflammatory mediators in chondrocytes.
Supporting Evidence
- Plasma samples after pomegranate extract ingestion inhibited IL-1β-induced PGE2 production in chondrocytes.
- COX-2 enzyme activity was significantly inhibited by plasma samples obtained after pomegranate extract supplementation.
- Bioavailable constituents of pomegranate extract were detected in plasma after oral ingestion.
Takeaway
Eating pomegranate can help reduce inflammation in your body by stopping certain chemicals that cause swelling.
Methodology
Rabbits were given pomegranate fruit extract, and their plasma was analyzed for its effects on COX enzyme activity and inflammatory mediator production in chondrocytes.
Limitations
The study was conducted on rabbits, and results may not directly translate to humans.
Participant Demographics
6 New Zealand white rabbits, male, 1 year old, average weight 3.7 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website