Gene Expression Differences in SIV Infections
Author Information
Author(s): Lederer Sharon, Favre David, Walters Kathie-Anne, Proll Sean, Kanwar Bittoo, Kasakow Zeljka, Baskin Carole R., Palermo Robert, McCune Joseph M., Katze Michael G.
Primary Institution: University of Washington
Hypothesis
How do gene expression patterns differ between natural and non-natural hosts during SIV infection?
Conclusion
The study found significant differences in gene expression patterns between African green monkeys and Asian pigtailed macaques during SIV infection, suggesting mechanisms for disease resistance.
Supporting Evidence
- SIV infection leads to AIDS in macaques, while African green monkeys show limited disease.
- Gene expression changes were primarily observed in lymph nodes at peak viral load.
- Pathogenic infections showed a shift towards stress pathways and Th1 profiles.
- Non-pathogenic infections exhibited controlled immune responses and better cell homeostasis.
- Over 600 genes were expressed at significantly different levels between species at peak viral load.
Takeaway
This study looked at how two types of monkeys respond to a virus. One type gets sick, while the other stays healthy, and they react differently at the gene level.
Methodology
Transcriptional profiling was performed on lymph node, blood, and colon samples from both species infected with SIV.
Participant Demographics
Four African green monkeys and four Asian pigtailed macaques were used in the study.
Statistical Information
P-Value
p≤0.05
Statistical Significance
p<0.02
Digital Object Identifier (DOI)
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