Impact of Sidedness of Colon Cancer on Outcomes
Author Information
Author(s): de Moraes Filho Oswaldo, Alves Martins Bruno Augusto, Silva André Araujo de Medeiros, Nóbrega dos Santos Antonio Carlos, de Almeida Romulo Medeiros, Sousa João Batista, Coppola Francesca, Faggioni Lorenzo
Primary Institution: University Hospital of Brasília, University of Brasilia, Brasília, Brazil
Hypothesis
The study aims to identify differences between right and left colon cancer in terms of clinical presentation, surgical results, and survival outcomes.
Conclusion
The study found no significant impact of colon cancer sidedness on overall survival and disease-free survival.
Supporting Evidence
- Right colon cancer presented less bleeding and fewer changes in bowel habits compared to left colon cancer.
- Patients with left colon cancer had more poorly differentiated tumors.
- Overall survival and disease-free survival did not differ significantly between right-sided and left-sided colon cancer.
Takeaway
This study looked at patients with colon cancer and found that whether the cancer is on the right or left side doesn't really change how long people live after treatment.
Methodology
The study was a retrospective cohort analysis of patients with colon cancer stages I-IV from a single center, comparing right and left-sided cancers.
Potential Biases
Potential biases may arise from the retrospective nature of the study and the exclusion of certain patient groups.
Limitations
The study is retrospective and has a relatively small sample size, which may affect the generalizability of the results.
Participant Demographics
Patients aged 18 years and older diagnosed with adenocarcinoma of the colon, with a mean age of 62.20 for right-sided and 60.13 for left-sided cancers.
Statistical Information
P-Value
p: 0.4490 for OS; p: 0.0814 for DFS
Confidence Interval
CI: 0.61–3.01 for OS; CI: 0.91–4.59 for DFS
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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