Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9)
2008
Study of the ASAP Protein in Cell Division
publication
Evidence: high
Author Information
Author(s): Magali Venoux, Karine Delmouly, Ollivier Milhavet, Sophie Vidal-Eychenié, Dominique Giorgi, Sylvie Rouquier
Primary Institution: Institut de Génétique Humaine, CNRS UPR 1142, Montpellier, France
Hypothesis
The ASAP protein is essential for proper cell cycling and may play a role in DNA damage response.
Conclusion
ASAP is conserved across vertebrates and is crucial for mitosis, with potential implications in cancer treatment and neurodegenerative diseases.
Supporting Evidence
- ASAP is strongly expressed in brain and testis, indicating its importance in tissues rich in microtubules.
- Overexpression of ASAP leads to mitotic defects, similar to those observed in human cells.
- ASAP is involved in the organization of the mitotic spindle and cytokinesis.
Takeaway
ASAP is a protein that helps cells divide correctly, and if it doesn't work right, it can lead to problems like cancer.
Methodology
The study involved cloning cDNAs from mouse and Xenopus, analyzing gene structure, and characterizing tissue expression.
Digital Object Identifier (DOI)
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