Genome Scan Linkage Results for Blood Pressure in Framingham Study
Author Information
Author(s): James Katherine, Weitzel Lindsay-Rae B, Engelman Corinne D, Zerbe Gary, Norris Jill M
Primary Institution: Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center
Hypothesis
This study aims to identify genomic regions influencing the rate of change in resting systolic blood pressure in families from the Framingham Heart Study.
Conclusion
The study found significant evidence for linkage between systolic blood pressure rate of change and a region on chromosome 1.
Supporting Evidence
- Systolic blood pressure is a more important determinant of cardiovascular risk than diastolic blood pressure.
- Longitudinal blood pressure measurements provide a better risk assessment than single measures.
- The study utilized mixed model methodology to analyze the data over time.
Takeaway
Researchers looked at how blood pressure changes over time in families and found a specific area in our genes that might affect this change.
Methodology
The study used linear mixed models to analyze systolic blood pressure data collected over time from subjects in the Framingham Heart Study.
Potential Biases
Measurements from individuals on hypertension medication may introduce bias in the results.
Limitations
The study's findings may be influenced by missing data and the treatment of subjects for hypertension.
Participant Demographics
Subjects were derived from Cohort 2 of the Framingham Heart Study, primarily consisting of offspring with a higher proportion of siblings.
Statistical Information
P-Value
0.00002
Statistical Significance
p = 0.00002
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website