HIC-1 Gene and Breast Cancer Outcomes
Author Information
Author(s): Nicoll G, Crichton D N, McDowell H E, Kernohan N, Hupp T R, Thompson A M
Primary Institution: University of Dundee
Hypothesis
Does the expression of the HIC-1 gene correlate with better outcomes in breast cancer patients?
Conclusion
The presence of HIC-1 expression in breast cancer patients is associated with a better survival rate.
Supporting Evidence
- HIC-1 expression was detected in only 14% of the breast cancer samples.
- All patients with HIC-1 expression were alive without disease recurrence after 8 years.
- Five out of seven patients with HIC-1 expression had detectable wild type p53 mRNA.
Takeaway
If a breast cancer patient has a gene called HIC-1, they might live longer without their cancer coming back.
Methodology
RT-PCR analysis was used to examine HIC-1 expression in RNA extracted from breast cancer samples.
Limitations
The study had a small sample size and the presence of 17p13.3 loss of heterozygosity in some patients complicates the interpretation of results.
Participant Demographics
The study involved 50 primary untreated human breast cancer patients.
Digital Object Identifier (DOI)
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