Corticosteroid-Induced Psychiatric Disorders: Mechanisms, Outcomes, and Clinical Implications
Author Information
Author(s): Nasereddin Lara, Alnajjar Omar, Bashar Homam, Abuarab Sara Feras, Al-Adwan Rahma, Chellappan Dinesh Kumar, Barakat Muna
Primary Institution: Applied Science Private University, Jordan
Hypothesis
How do corticosteroids influence psychiatric disorders through their effects on the HPA axis and neurotransmitter levels?
Conclusion
Corticosteroids can cause significant psychiatric side effects, including mood disturbances, anxiety, and psychosis, which require careful monitoring and management.
Supporting Evidence
- Corticosteroids can cause mood disturbances, anxiety, and psychosis.
- Psychiatric symptoms often appear within 3–4 days of starting corticosteroid therapy.
- Long-term corticosteroid use is linked to higher incidences of depression and anxiety.
- Healthcare providers need to monitor patients for psychiatric symptoms when prescribing corticosteroids.
- Different corticosteroid types and dosages can lead to varying psychiatric outcomes.
- Patient education is crucial to mitigate the risks associated with corticosteroid therapy.
Takeaway
Corticosteroids, often used to treat various health issues, can also make people feel sad or anxious, so doctors need to watch for these side effects.
Methodology
The review synthesized existing literature on corticosteroid-induced neuropsychiatric outcomes, focusing on their impact on the HPA axis and brain function.
Potential Biases
Observational studies may introduce confounding factors.
Limitations
Potential publication bias and variability in study designs may limit the ability to infer causality.
Digital Object Identifier (DOI)
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