Probiotic Bacteria and Their Impact on Inflammation in the Gut
Author Information
Author(s): Hörmannsperger Gabriele, Clavel Thomas, Hoffmann Micha, Reiff Caroline, Kelly Denise, Loh Gunnar, Blaut Michael, Hölzlwimmer Gabriele, Laschinger Melanie, Haller Dirk
Primary Institution: Technische Universität München
Hypothesis
What are the molecular mechanisms underlying the anti-inflammatory potential of the probiotic mixture VSL#3 in intestinal epithelial cells?
Conclusion
The study demonstrates that the probiotic L. casei inhibits the secretion of the pro-inflammatory chemokine IP-10, which may contribute to its anti-inflammatory effects.
Supporting Evidence
- VSL#3 was shown to inhibit TNF-induced secretion of IP-10 in intestinal epithelial cells.
- L. casei was identified as the effective strain in the probiotic mixture for reducing IP-10 secretion.
- Feeding studies indicated that VSL#3 has segment-specific effects on inflammation in mice.
- IP-10 protein expression was reduced in primary epithelial cells treated with VSL#3.
Takeaway
Probiotic bacteria can help reduce inflammation in the gut by stopping the release of certain harmful proteins.
Methodology
The study used cell culture experiments with intestinal epithelial cells and animal models to analyze the effects of VSL#3 on IP-10 secretion.
Potential Biases
Potential bias in the selection of bacterial strains and experimental conditions.
Limitations
The study primarily focused on specific bacterial strains and may not generalize to all probiotics.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website