MRI Strain Analysis for Heart Function After Stem Cell Therapy
Author Information
Author(s): Bhatti Sabha, Hakeem Abdul, Taylor Michael, Chung Eugene, Quyyumi Arshed A, Oshinski John, Pecora Andrew L, Kereiakes Dean, Hor Kan, Mazur Wojciech
Primary Institution: University of Cincinnati Hospital
Hypothesis
Can MRI strain analysis detect improvements in myocardial function following stem cell therapy?
Conclusion
MRI strain analysis showed significant improvement in heart function in patients receiving stem cell therapy compared to controls.
Supporting Evidence
- Thirteen patients in the treatment and 11 controls were available for strain analysis.
- Mean apical circumferential strain increased from -17.2 to -20.6 at 6 months.
- Mid anterior circumferential strain showed a trend to improvement from baseline to 3 months.
Takeaway
Doctors used a special MRI technique to see if heart function got better after stem cell treatment, and it did for some patients.
Methodology
The study randomized 31 patients to receive either stem cell therapy or control treatment and measured myocardial strain using MRI at baseline, 3 months, and 6 months.
Limitations
The study had a small patient population.
Participant Demographics
Patients were randomized and included both genders with an average age of around 52 years.
Statistical Information
P-Value
0.03
Confidence Interval
95% CI -22.2, -12.1
Statistical Significance
p=0.03
Digital Object Identifier (DOI)
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