Influenza Virus Infection and TNF Production
Author Information
Author(s): K.N. Masihi, H. Hintelmann, K. Madaj, G. Gast
Primary Institution: Robert Koch Institute, Berlin, Germany
Hypothesis
The study investigates the effect of influenza virus infection on the production of tumor necrosis factor (TNF) in response to bacterial stimuli.
Conclusion
Influenza virus infection significantly increases TNF production in response to bacterial lipopolysaccharide (LPS) in mice.
Supporting Evidence
- Significant TNF production was observed 72 hours after influenza virus infection.
- TNF levels were higher in mice infected with influenza and then given LPS compared to those given only LPS.
- TNF production was blocked by a specific anti-TNF monoclonal antibody.
Takeaway
When mice get the flu, their bodies make more of a substance called TNF when they also get bacteria, which can make them sicker.
Methodology
Mice were infected with influenza virus and then given LPS to measure TNF production.
Limitations
The study was conducted on mice, which may not fully represent human responses.
Participant Demographics
Four- to 5-week-old female NMRI mice.
Statistical Information
P-Value
p<0.0012
Statistical Significance
p<0.0012
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