L-myc DNA Polymorphism and Metastasis in Lung Cancer Patients
Author Information
Author(s): T. Tefre, A.-L. B0rresen, S. Aamdal, A. Br0gger
Primary Institution: Norwegian Radium Hospital
Hypothesis
Is there a correlation between the L-myc S-allele and increased risk for metastasis in lung cancer patients?
Conclusion
The study found no correlation between the L-myc S-allele and increased metastasis in lung cancer patients.
Supporting Evidence
- No association was found between the L-myc RFLP and increased risk of metastasis.
- There was no difference in survival time between the three different genotypes.
- The frequency of the L and S alleles was similar in lung cancer patients and controls.
Takeaway
Researchers looked at lung cancer patients to see if a specific gene variant made it more likely for the cancer to spread, but they found it didn't.
Methodology
Blood samples were collected from lung cancer patients and controls, and DNA was analyzed for the L-myc EcoRI polymorphism.
Limitations
The study had a small sample size and included only advanced lung cancer cases, which may limit the findings.
Participant Demographics
The study included 73 men and 10 women, aged 43-85, all Norwegian Caucasians.
Statistical Information
P-Value
P=0.88
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