Characterization of the Shewanella oneidensis Fur gene: roles in iron and acid tolerance response
2008
Understanding the Fur Gene in Shewanella oneidensis
publication
Evidence: moderate
Author Information
Author(s): Yang Yunfeng, Harris Daniel P, Luo Feng, Wu Liyou, Parsons Andrea B, Palumbo Anthony V, Zhou Jizhong
Primary Institution: Biosciences Division, Oak Ridge National Laboratory
Hypothesis
What roles does the Fur gene play in iron and acid tolerance response in Shewanella oneidensis?
Conclusion
The study shows that the Fur gene is involved in iron acquisition and acid tolerance response in Shewanella oneidensis.
Supporting Evidence
- The fur mutant showed growth deficiencies in iron-rich and acidic environments.
- Gene expression studies indicated that iron uptake genes were highly de-repressed in the fur mutant.
- Many genes involved in energy metabolism were found to be iron-responsive but Fur-independent.
Takeaway
The Fur gene helps bacteria manage iron and survive in acidic environments, which is important for their growth.
Methodology
Physiological and transcriptomic studies were conducted, including microarray experiments to analyze gene expression.
Statistical Information
P-Value
1.4E-05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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