Pregabalin for Migraine Prevention
Author Information
Author(s): Pizzolato Raffaella, Villani Veronica, Prosperini Luca, Ciuffoli Alessandro, Sette Giuliano
Primary Institution: S. Andrea Hospital, Sapienza University, Rome, Italy
Hypothesis
Is pregabalin effective and tolerable as a preventive treatment for migraine?
Conclusion
Pregabalin may be an effective and well-tolerated preventive treatment for migraine.
Supporting Evidence
- Pregabalin was started at 75 mg/day and increased to 300 mg/day as tolerated.
- 13% of patients reported side effects, with three discontinuing due to intolerable effects.
- A significant reduction in migraine frequency was observed after 1 and 3 months of treatment.
Takeaway
This study looked at whether a medicine called pregabalin can help people with migraines. It found that it can reduce the number of headaches people have.
Methodology
Patients with migraine were treated with pregabalin, starting at 75 mg/day and titrated to 300 mg/day over three months, with data collected on headache frequency and side effects.
Potential Biases
The open-label design may introduce bias in reporting outcomes.
Limitations
The study had a small sample size and was uncontrolled and open-label.
Participant Demographics
The study included 47 patients, with a mean age of 48 years, consisting of 10 males and 37 females.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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