Alternative Mating Type Configurations of Candida albicans Result in Different Biofilms
Author Information
Author(s): Yi Song, Nidhi Sahni, Karla J. Lu, Kevin L. Srikantha, Thyagarajan Huang, Guanghua Garnaas, Adam M. Soll, David R. Soll
Primary Institution: Department of Biology, The University of Iowa, Iowa City, Iowa, United States of America
Hypothesis
C. albicans forms two alternative biofilms depending upon mating configuration.
Conclusion
C. albicans forms two morphologically similar but functionally distinct biofilms, depending on the configuration of the mating type locus.
Supporting Evidence
- Biofilms formed by a/α cells are impermeable to antifungals and resistant to human immune cells.
- a/a or α/α biofilms are permeable and susceptible to antifungals.
- The formation of a/α biofilms is regulated by the Ras1/cAMP pathway.
- The formation of a/a biofilms is regulated by the MAP kinase pathway.
- Both types of biofilms exhibit different characteristics and serve different purposes.
Takeaway
Candida albicans can create two types of biofilms that look alike but behave very differently, depending on their genetic makeup.
Methodology
Biofilms were developed on silicone elastomer surfaces and analyzed for permeability, thickness, and susceptibility to antifungals.
Digital Object Identifier (DOI)
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