Comparing Two Forms of Malaria Treatment in Children
Author Information
Author(s): Juma Elizabeth A, Obonyo Charles O, Akhwale Willis S, Ogutu Bernhards R
Primary Institution: Kenya Medical Research Institute
Hypothesis
Is the artemether-lumefantrine suspension as effective as the tablets for treating uncomplicated malaria in children?
Conclusion
The artemether-lumefantrine suspension was not superior to the tablets for treating uncomplicated malaria in young children.
Supporting Evidence
- Both treatments effectively cleared gametocytes and were well tolerated.
- The PCR-corrected cure rate was 96.0% for tablets and 93.4% for suspension at Day 28.
- No significant difference in adverse events between the two treatment groups.
Takeaway
This study looked at two ways to treat malaria in kids: one with tablets and one with a liquid. Both worked well, but the liquid wasn't better than the tablets.
Methodology
A randomized, controlled, open-label trial comparing the efficacy of artemether-lumefantrine tablets and suspension in treating malaria in children.
Potential Biases
Parents were aware of their children's treatment assignment, which could influence reporting of outcomes.
Limitations
The open-label design could introduce bias, and the sample size may not have been sufficient to detect significant differences.
Participant Demographics
Children aged 6–59 months, predominantly rural population in western Kenya.
Statistical Information
P-Value
0.40
Confidence Interval
95% CI 90.8 – 98.7 for tablets; 95% CI 87.4 – 97.1 for suspension
Statistical Significance
p = 0.40
Digital Object Identifier (DOI)
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