Vaginal Flora in Postmenopausal Women: The Effect of Estrogen Replacement
Author Information
Author(s): Paul D. Ginkel, David E. Soper, Richard C. Bump, Harry P. Dalton
Primary Institution: Medical College of Virginia, Virginia Commonwealth University
Hypothesis
What is the effect of estrogen replacement therapy on the vaginal flora of postmenopausal women?
Conclusion
Estrogen replacement therapy reduces the likelihood of vaginal colonization with anaerobic bacteria in postmenopausal women.
Supporting Evidence
- After 8 weeks of estrogen replacement therapy, the incidence of anaerobic species fell from 47% to 13%.
- The incidence of anaerobic gram-negative rods declined from 40% to 7% after treatment.
- Mean vaginal pH decreased significantly after estrogen replacement therapy.
Takeaway
This study found that giving estrogen to postmenopausal women helps reduce bad bacteria in their vagina.
Methodology
Vaginal cultures were taken from 15 postmenopausal women before and after 8 weeks of estrogen replacement therapy.
Limitations
The study had a small sample size and a short follow-up period.
Participant Demographics
Mean age of participants was 53.9 years; 60% were sexually active.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website