Effects of CPAP on Weight and Metabolism in Obese Sleep Apnea Patients
Author Information
Author(s): Garcia Jose M, Sharafkhaneh Hossein, Hirshkowitz Max, Elkhatib Rania, Sharafkhaneh Amir
Primary Institution: Michael E. DeBakey Veterans Affairs Medical Center
Hypothesis
CPAP will decrease insulin resistance, ghrelin and resistin levels and increase adiponectin levels in obese individuals with OSA.
Conclusion
Weight change rather than elimination of hypoxia modulated alterations in insulin resistance in obese patients with OSA during the first six months of CPAP therapy.
Supporting Evidence
- CPAP improved hypoxia but increased insulin and insulin resistance.
- Fasting ghrelin decreased significantly while other hormones remained unchanged.
- 40% of patients gained weight significantly during the study.
Takeaway
This study found that using a CPAP machine for sleep apnea didn't help obese patients lose weight or improve their insulin resistance, which is important for diabetes.
Methodology
The study used a pre- and post-treatment design with hormonal assays in 20 obese subjects with OSA before and after 6 months of CPAP use.
Potential Biases
Potential bias due to the lack of a control group and the observational nature of the study.
Limitations
The small sample size and lack of data on changes in dietary habits and physical activity.
Participant Demographics
Participants were predominantly male (17 out of 20), with an average age of 59.7 years and a mean BMI of 36.5.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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