TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
2008
TAF3 Interacts with p53 and Inhibits Its Function
publication
Evidence: high
Author Information
Author(s): Bereczki Orsolya, Ujfaludi Zsuzsanna, Pardi Norbert, Nagy Zita, Tora Laszlo, Boros Imre M, Balint Eva
Primary Institution: University of Szeged
Hypothesis
How does TAF3 interact with p53 and affect its transcriptional activity?
Conclusion
TAF3 is identified as a negative regulator of p53 transcription activation function.
Supporting Evidence
- TAF3 interacts with both Drosophila and human p53.
- Elevated TAF3 expression inhibits transcription activation by p53 in human cell lines.
- TAF3 decreases the level of the p53 protein without affecting its mRNA level.
Takeaway
TAF3 is a protein that can stop another protein called p53 from doing its job, which is to help protect cells from damage.
Methodology
Yeast two-hybrid assays and in vitro binding assays were used to study the interactions between TAF3 and p53.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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