Successful pregnancy of an SMA type 3 sitter on Nusinersen therapy - a case report
2025
Successful Pregnancy of an SMA Type 3 Patient on Nusinersen Therapy
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Hiebeler Miriam, Thiele Simone, Walter Maggie C.
Primary Institution: Ludwig-Maximilians-University of Munich
Hypothesis
Can Nusinersen therapy be safely continued during pregnancy in SMA patients?
Conclusion
The case demonstrates a successful pregnancy outcome for a patient with SMA type 3 who was treated with Nusinersen.
Supporting Evidence
- The patient had a healthy child born via caesarean section.
- Nusinersen treatment was paused during pregnancy and restarted after delivery.
- Motor function deteriorated during pregnancy but stabilized post-treatment.
Takeaway
A woman with a type of muscle disease became pregnant while on a specific treatment, and both she and her baby were healthy after birth.
Methodology
Case report detailing the patient's treatment and pregnancy outcomes.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
33-year-old female patient with SMA type 3.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website