Per vaginal bleeding-an important but ignored feature of dengue
2024

Per vaginal bleeding and dengue severity

Sample size: 288 publication Evidence: moderate

Author Information

Author(s): Wijewickrama Ananda, Kuruppu Heshan, Idampitiya Damayanthi, Wickramanayake Rivindu, Kottahachchi Anagi Shakya, Jayamali Jeewantha, Chathurangika Padukkage Harshani, Senatilleke Nushara, Warnakulasuriya Navanjana, Jeewandara Chandima, Malavige Gathsaurie Neelika

Primary Institution: National Institute of Infectious Diseases Sri Lanka

Hypothesis

What is the frequency and impact of per vaginal bleeding in women with dengue?

Conclusion

PV bleeding is linked to worse disease outcomes in dengue patients.

Supporting Evidence

  • 9.72% of women reported PV bleeding.
  • 42.85% of those with PV bleeding developed dengue hemorrhagic fever.
  • Women with PV bleeding were more likely to experience abdominal pain and vomiting.

Takeaway

Some women with dengue have vaginal bleeding, and it might make their illness worse.

Methodology

288 adult female patients were recruited, and clinical features and lab investigations were recorded during hospital admission.

Potential Biases

Potential biases in patient selection and reporting of symptoms.

Limitations

The study may not have captured all relevant complications and outcomes.

Participant Demographics

Adult female patients, including those of reproductive age.

Statistical Information

P-Value

0.06

Confidence Interval

95% CI 0.98 to 5.1

Statistical Significance

p=0.06

Digital Object Identifier (DOI)

10.1101/2024.12.23.24319534

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