Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and Leptin genes and up-regulation of the adiponectin gene
2008
Effects of Irvingia gabonensis Seed Extract on Fat Cell Development
Sample size: 3
publication
Evidence: moderate
Author Information
Author(s): Oben Julius E, Ngondi Judith L, Blum Kenneth
Primary Institution: University of Yaoundé I, Cameroon
Hypothesis
Does Irvingia gabonensis seed extract (IGOB131) inhibit fat cell development by affecting specific gene expressions?
Conclusion
IGOB131 may help control fat cell development and could have implications for obesity treatment by targeting specific genes.
Supporting Evidence
- IGOB131 significantly inhibited adipogenesis in adipocytes.
- The extract down-regulated PPAR gamma and leptin gene expressions.
- IGOB131 up-regulated adiponectin gene expression.
Takeaway
This study found that a natural extract from a plant can help stop fat cells from growing too much, which might help people who are overweight.
Methodology
The study used murine 3T3-L1 adipocytes to test the effects of IGOB131 on gene expressions related to fat cell development.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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