Naturally Acquired Human Plasmodium knowlesi Infection, Singapore
2008
Case of Plasmodium knowlesi Infection in Singapore
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Ng Oon Tek, Ooi Eng Eong, Lee Cheng Chuan, Lee Piao Jarrod, Ng Lee Ching, Pei Sze Wong, Tu Tian Ming, Loh Jin Phang, Leo Yee Sin
Primary Institution: Tan Tock Seng Hospital, Singapore
Hypothesis
Can Plasmodium knowlesi be a cause of malaria in a malaria-free country like Singapore?
Conclusion
This case confirms that Plasmodium knowlesi can cause malaria in Singapore, indicating the need for awareness of this emerging zoonotic disease.
Supporting Evidence
- The patient had fever, myalgia, and other symptoms consistent with malaria.
- Initial diagnosis was dengue fever, which was ruled out after further testing.
- PCR confirmed the presence of Plasmodium knowlesi in the patient's blood.
Takeaway
A soldier in Singapore got malaria from a monkey parasite, even though Singapore is supposed to be free of malaria.
Methodology
Diagnosis was confirmed by PCR with species-specific primers.
Limitations
The study is based on a single case report.
Participant Demographics
A previously healthy 20-year-old soldier.
Digital Object Identifier (DOI)
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