Thymidylate Synthase Expression in Colorectal Cancer
Author Information
Author(s): Liu Yanyan, Xia Qingxin, Jia Yanzhao, Guo Hongqiang, Wei Bing, Hua Yawei, Yang Shujun
Primary Institution: Henan Provincial Cancer Hospital, Henan Provincial Institute of Cancer
Hypothesis
Higher thymidylate synthase expression in primary tumors correlates with better outcomes in colorectal cancer patients.
Conclusion
Patients with higher thymidylate synthase expression in primary tumors had better outcomes after adjuvant chemotherapy.
Supporting Evidence
- 39.47% of patients had higher TS expression in primary tumors.
- 42.11% of patients showed differential TS expression between normal mucosa and primary tumor cells.
- High frequency of microsatellite instability was found in 32.89% of patients.
- Patients with higher TS expression had longer median relapse-free survival.
Takeaway
This study found that patients with more thymidylate synthase in their tumors tend to do better after treatment for colorectal cancer.
Methodology
Laser capture microdissection and polymerase chain reaction were used to examine TS gene expression.
Participant Demographics
{"median_age":58,"male_percentage":55.26,"tumor_site":{"colon":27.63,"rectum":72.37},"staging":{"high_risk_II":65.79,"III":34.21}}
Statistical Information
P-Value
{"higher_TS_expression":{"stage":0.018,"histological_grade":0.001,"MSI":0.0},"RFS":0.03,"OS":0.029}
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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