Effects of Dietary Oils on Mouse Liver Genes
Author Information
Author(s): Alvin Berger, Matthew A. Roberts, Bruce Hoff
Primary Institution: Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA
Hypothesis
How do dietary arachidonic- and docosahexaenoic-acid rich oils affect the murine hepatic transcriptome?
Conclusion
Different dietary oils have unique effects on liver metabolism and gene expression in mice.
Supporting Evidence
- 371 probe sets were changed by dietary treatment.
- FISH increased transcripts linked to combating oxidative stress.
- COMB diet was most effective at down regulating fatty acid synthesis.
Takeaway
Eating different types of oils can change how our liver works and which genes are active.
Methodology
Mice were fed diets enriched with fungal oil, fish oil, or a combination, and their liver gene expression was analyzed using microarray technology.
Limitations
The study is limited to mouse models and may not directly translate to humans.
Participant Demographics
Mice were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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