Microsomal epoxide hydrolase gene polymorphism and susceptibility to colon cancer
1999
Microsomal Epoxide Hydrolase Gene and Colon Cancer Risk
Sample size: 304
publication
Evidence: moderate
Author Information
Author(s): Harrison D J, Hubbard A L, MacMillan J, Wyllie A H, Smith C A D
Primary Institution: CRC Laboratories, Department of Pathology, University of Edinburgh
Hypothesis
Does the polymorphism in the microsomal epoxide hydrolase gene increase susceptibility to colon cancer?
Conclusion
The study found that a specific mutation in the microsomal epoxide hydrolase gene is associated with an increased risk of colon cancer.
Supporting Evidence
- The frequency of the exon 3 T to C mutation was higher in cancer patients than in controls.
- This mutation is associated with lower enzyme activity when expressed in vitro.
- The association was more apparent for tumours arising distally.
Takeaway
Some people have a change in a gene that might make them more likely to get colon cancer.
Methodology
The study examined gene polymorphisms in 101 colon cancer patients and compared them with 203 control samples.
Participant Demographics
101 patients with colon cancer and 203 control samples
Statistical Information
Confidence Interval
95% CI 1.8–8.0
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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