Prevalence of Red Cell Alloantibodies in Blood Recipients in Kelantan, Malaysia
Author Information
Author(s): Al-Joudi Fawwaz, Anuar Bin Ramli, Ahmed Suhair, Ismail Mohd
Primary Institution: National University of Malaysia
Hypothesis
What is the prevalence of red cell alloantibodies among blood recipients in Kelantan?
Conclusion
The study found that 1.13% of blood recipients had red cell alloantibodies, with multiple transfusions and pregnancies being significant factors for their formation.
Supporting Evidence
- The overall prevalence of alloimmunization was found to be 1.13%.
- 76.9% of patients with alloantibodies had a single alloantibody.
- Anti-E was the most common alloantibody detected.
Takeaway
This study looked at how many people getting blood transfusions in Kelantan have special antibodies that can cause problems. They found that a small number do, and it often happens after many transfusions or during pregnancy.
Methodology
A retrospective cross-sectional study analyzing data from antibody screening tests of 5719 patients.
Potential Biases
Potential bias due to the retrospective nature of the study and exclusion of patients with missing data.
Limitations
The study is limited to data from two years and may not represent current trends.
Participant Demographics
The majority of participants were female, predominantly Malays, with a mean age of 39.12 years.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI: 0.8-1.4
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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