p53 in Colorectal Cancer
Author Information
Author(s): N. Scott, P. Sagar, J. Stewart, G.E. Blair, M.F. Dixon, P. Quirke
Primary Institution: University of Leeds
Hypothesis
The study aims to assess the relationship between p53 expression and various clinicopathological variables in colorectal cancer.
Conclusion
p53 protein was found in 42% of colorectal adenocarcinomas, with no correlation to patient survival or several other clinical factors.
Supporting Evidence
- p53 was detected in 42% of colorectal adenocarcinomas.
- Positive tumours were more frequent in the distal colon.
- No correlation was found with tumour grade or patient survival.
- Left sided cancers expressed p53 more often than right sided lesions.
Takeaway
This study looked at a protein called p53 in cancer samples from the colon and found it in about half of the cases, but it didn't help predict how well patients would do.
Methodology
Immunohistochemistry was used to detect p53 in frozen sections of colorectal adenocarcinomas from 52 patients.
Limitations
The study did not find a correlation between p53 expression and several established prognostic indicators.
Participant Demographics
Median age was 69 years, with 52% male participants.
Statistical Information
P-Value
P<0.05
Statistical Significance
p<0.05
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