MCT1 Gene and Athletic Performance in Japanese Runners
Author Information
Author(s): Seki Shotaro, Kobayashi Tetsuro, Beppu Kenji, Nojo Manabu, Hoshina Kosaku, Kikuchi Naoki, Okamoto Takanobu, Nakazato Koichi, Hwang Inkwan
Primary Institution: Nippon Sport Science University
Hypothesis
The frequency of the AA genotype in the T1470A polymorphism increases with higher competitive levels among Japanese long-distance runners.
Conclusion
The AA genotype of the T1470A polymorphism is associated with higher athletic status and better physiological parameters in Japanese long-distance runners.
Supporting Evidence
- The AA genotype showed significantly higher values for oxygen uptake at lactate threshold.
- Subjects with the AA genotype had higher maximal oxygen uptake compared to T allele carriers.
- The frequency of the AA genotype increased with higher competitive levels among runners.
- Physiological parameters were significantly better in AA genotype carriers than in T allele carriers.
Takeaway
This study found that runners with a specific gene variant (AA genotype) perform better in long-distance running than those without it.
Methodology
A case-control study comparing 158 long-distance runners with 649 individuals from the general population, using genetic analysis and physiological testing.
Potential Biases
Potential selection bias due to voluntary participation.
Limitations
The physiological parameters were measured only in voluntarily participating runners, which may introduce bias.
Participant Demographics
158 male Japanese long-distance runners aged 26.1 ± 9.9 years and 649 general Japanese individuals (271 men, 378 women).
Statistical Information
P-Value
0.001, 0.01, 0.005, 0.038
Confidence Interval
95% CI: 1.91–7.18, 0.72–5.09, 1.20–5.80, 0.08–2.77
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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