Role of Circulating Tumor Cells and Cell-Free DNA in Oral Squamous Cell Carcinoma
Author Information
Author(s): Eboshida Natsuki, Hamada Atsuko, Higaki Mirai, Obayashi Fumitaka, Ito Nanako, Yamasaki Sachiko, Tani Ryouji, Shintani Tomoaki, Koizumi Koichi, Yanamoto Souichi
Primary Institution: Hiroshima University, Hiroshima, Japan
Hypothesis
This study aimed to determine the potential role of liquid biopsy, circulating tumor cells, and cell-free DNA as biomarkers of oral squamous cell carcinoma.
Conclusion
The increased number of circulating tumor cell clusters and cell-free DNA levels may help inform management decisions regarding metastasis in oral squamous cell carcinoma.
Supporting Evidence
- Circulating tumor cells were detected in 100% of the cases.
- The number of circulating tumor cell clusters was higher in metastatic cases compared to non-metastatic cases.
- The amount of cell-free DNA was significantly higher in patients with distant metastasis.
Takeaway
Doctors are looking at tiny pieces of cancer cells and DNA in the blood to see if they can help figure out how bad the cancer is and how to treat it.
Methodology
The study involved collecting plasma samples from 13 patients with oral squamous cell carcinoma before and after surgery to analyze circulating tumor cells and cell-free DNA.
Limitations
The study had a small sample size and short-term follow-up.
Participant Demographics
{"median_age":73,"age_range":"58–88","sex_distribution":{"male":9,"female":4},"cancer_stage_distribution":{"stage_I":2,"stage_II":1,"stage_III":2,"stage_IV":8}}
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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