Conscientiousness Moderates the Relationship Between Interleukin-6 and Memory Decline
2024

Conscientiousness and Memory Decline

Sample size: 182 publication Evidence: moderate

Author Information

Author(s): Segerstrom Suzanne

Primary Institution: Oregon State University

Hypothesis

Does conscientiousness moderate the relationship between interleukin-6 and memory decline?

Conclusion

Conscientiousness and interleukin-6 have a synergistic effect on memory decline over time, with high conscientiousness helping to maintain memory performance.

Supporting Evidence

  • High conscientiousness and low IL-6 helped maintain memory performance over time.
  • The interaction between conscientiousness and IL-6 was significant for both total learning and delayed recall.
  • The effect of conscientiousness on memory decline was gender-specific.

Takeaway

Being organized and careful can help older people keep their memory sharp, especially if they don't have high levels of a certain inflammation marker.

Methodology

Rey Auditory Verbal Learning Test performance was measured annually for up to 16.6 years, analyzing the interactions between IL-6, conscientiousness, and gender.

Potential Biases

Potential biases in self-reported measures and the specific demographic of older adults may limit generalizability.

Limitations

The study may not account for all factors influencing memory decline and relies on self-reported conscientiousness.

Participant Demographics

Older adults with a mean age of 74 years, 41% female.

Statistical Information

P-Value

0.021, 0.024, 0.027

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1093/geroni/igae098.4145

Want to read the original?

Access the complete publication on the publisher's website

View Original Publication