Regulation of Peripheral Inflammation by Spinal p38 MAP Kinase in Rats
2006
Spinal Delivery of p38: TNF-alpha Inhibitors
publication
Author Information
Author(s): Edward Tobinick
Primary Institution: Institute for Neurological Research, Los Angeles, California, United States of America
Hypothesis
Spinal delivery of p38 inhibitors may be more effective than systemic delivery in treating spinally-mediated inflammatory mechanisms.
Conclusion
The study suggests that spinal delivery of p38 inhibitors could effectively target inflammation and pain in the spinal cord.
Supporting Evidence
- Previous studies suggest that p38 activation occurs predominantly in microglia.
- Spinal delivery may bypass the blood-brain barrier, enhancing treatment efficacy.
- Pilot studies indicate rapid clinical effects from perispinal administration of etanercept.
Takeaway
This study shows that giving certain medicines directly to the spine might work better than taking them through the body to help with pain and inflammation.
Potential Biases
The author has pending and issued patents related to the study, which may introduce bias.
Digital Object Identifier (DOI)
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