Effects of Exercise on Inflammation and Renal Function in Patients with Intermittent Claudication
Author Information
Author(s): Collins Patrick, Ford Isobel, Croal Bernard, Ball Derek, Greaves Michael, Macaulay Ewan, Brittenden Julie
Primary Institution: University of Aberdeen
Hypothesis
The study aimed to investigate the effects of treadmill exercise on markers of coagulation activation, inflammation, and renal function in patients with intermittent claudication receiving aspirin and statin therapy compared to healthy controls.
Conclusion
Exercise did not increase inflammatory markers in patients with intermittent claudication on statin and aspirin therapy, but it did result in a transient increase in glomerular permeability.
Supporting Evidence
- Patients with intermittent claudication had elevated baseline levels of inflammatory markers compared to healthy volunteers.
- Exercise did not increase Hs-CRP or IL-6 levels in either group.
- D-dimer levels increased in both groups following exercise, indicating a pro-thrombotic state.
- Urinary albumin and protein levels increased post-exercise in patients with intermittent claudication.
Takeaway
Doctors wanted to see if exercise would make patients with leg pain feel worse, but it didn't make their inflammation worse, even though it did change some kidney markers for a little while.
Methodology
20 patients with intermittent claudication and 20 healthy volunteers underwent treadmill exercise, with blood and urine samples taken before, immediately after, and one hour post-exercise to measure various markers.
Potential Biases
Potential selection bias due to the specific inclusion criteria for patients and volunteers.
Limitations
The study had a small sample size and was observational, which may limit the generalizability of the findings.
Participant Demographics
20 patients with intermittent claudication (16 males, 4 females, mean age 68) and 20 healthy volunteers (11 males, 9 females, mean age 63).
Statistical Information
P-Value
p = 0.001 for IL-6, p = 0.035 for HsCRP, p = 0.003 for D-dimer
Statistical Significance
p < 0.007
Digital Object Identifier (DOI)
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